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and pubertal abnormalities andpolycystic ovaries in females, were among the panopoly ofdiseases identified in excess. A synthetic form of this peptide (90–150 residues),exposed to acetonitrile treatment to increase ?-sheet content, is the only synthetically generated peptide that, when injected intracerebrally intoP102L-transgenic mice, is able to induce the GSS disease. Rare Diseases Strategy of the National Health System of Spain [in Spanish]. Extending Timay not increase VT but only maintain a volumeplateau. The effect of tissue compression on circularstapler line failure
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thefree ribosomes within the keratinocytes begin to synthesizekeratohyalin granules that become the distinctive featureof the cells in the stratum granulosum (Plate 42, page 514).Keratohyalin granules contain the two major intermediatefilament—associated proteins, filaggrin and trichohyalin.The appearance of the granules and expression of filaggrin inthe keratinocytes are often used as a clinical marker for the ini-tiation of the final stage of apoptosis.
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